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The bronchial tubes are the networks of branching tubes which deliver air to the tiny sacs of the lungs (alveoli). In bronchiectasis, the diameter of the bronchi is unusually large. Examination of the walls of the bronchial tubes reveals destruction of the normal structural elements, with replacement by scar tissue. Pus collects within the bronchi, and the normal flow of oxygen into the lungs, and carbon dioxide out of the lungs (air exchange) is impaired. The bronchi show signs of inflammation, with swelling and invasion by a variety of immune cells. The inflamed areas show signs of increased growth of blood vessels. The area of the lung which should be served by a diseased bronchial tube is also prone to inflammation and infection.
Prior to the widespread use of immunizations, bronchiectasis was often the result of a serious infection with either measles or whooping cough. Currently, viruses that cause influenza (flu) or influenza-like syndromes, as well as a number of bacteria may precede the development of bronchiectasis. Patients who have been infected with tuberculosis or the virus which causes AIDS (HIV or human immunodeficiency virus) also have an increased chance of bronchiectasis.
A number of pre-existing conditions may cause an individual to be more susceptible than normal to infection, with increased risk of bronchiectasis developing. These conditions include disorders of cilia, and immune disorders.
Cilia are the tiny hairs which usually line the bronchial tubes. Cilia wave constantly, sweeping the bronchial tubes clean of bacterial or viral invaders, and cleaning away excess secretions (mucus, sputum) which may be produced by the bronchi. When these cilia are abnormal or absent at birth, various bacterial or viral invaders may remain in the respiratory tract, multiply, and cause serious infections.
Immune disorders include decreased production of certain immune chemicals (immunoglobulins) which usually serve to fight off infection by bacterial or viral invasion. When these immunoglobulins are not produced in large enough quantity, bacterial and viral invaders are not effectively killed off, and infection occurs.
Other causes of bronchiectasis include an abnormally blocked (obstructed) airway. This can be due to tumor growth within the bronchial tube, or due to a child accidentally inhaling a small object which then blocks off the bronchial tube. People with the disease called cystic fibrosis (CF) often have their bronchial tubes obstructed by the thick, sticky mucus which is a hallmark of CF. Toxic exposures (breathing ammonia, for example) can harm the bronchi, and lead to bronchiectasis. An extreme allergic response of the immune system to the presence of certain fungi (especially one called Aspergillus) can also damage the bronchial tubes enough to result in bronchiectasis.
Symptoms of bronchiectasis include constant cough and the production of infected sputum (sputum is a mixture of mucus and pus), which may be bloody. In some cases, there may be wheezing and shortness of breath. The constant, low-level of infection may flare, resulting in increased production of sputum, worsening of the cough, and fever. The area of the lung served by the affected bronchial tube may become severely infected, resulting in pneumonia.
Author Info: Rosalyn Carson-DeWitt MD, The Gale Group Inc., Gale, Detroit, Gale Encyclopedia of Medicine, 2002
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