Join for Just $16 A Year
- Discounts on travel and everyday savings
- Subscription to AARP The Magazine
- Free membership for your spouse or partner
Toremifene is used as adjuvant hormone therapy immediately after surgery in early stages of breast cancer and also to treat advanced metastatic breast cancer (stages III and above) in postmenopausal women. Post-menopausal women at high risk of developing breast cancer may take toremifene to reduce risk.
Toremifene is similar to tamoxifen in structure and action. Toremifene can be given as sole treatment, but it
Toremifene belongs to a family of compounds called antiestrogens. Antiestrogens are used in cancer therapy by inhibiting the effects of estrogen on target tissues. Estrogen is a steroid hormone secreted by granulosa cells of a maturing follicle within the female ovary. Depending on the target tissue, estrogen can stimulate the growth of female reproductive organs and breast tissue, play a role in the female menstrual cycle, and protect against bone loss by binding to estrogen receptors on the outside of cells within the target tissue. Antiestrogens act selectively against the effects of estrogen on target cells in a variety of ways, thus they are called selective estrogen receptor modulators (SERMs).
Toremifene selectively inhibits the effects of estrogen on breast tissue, while mimicking the effects of estrogen on bone (by increasing bone mineral density) and uterine tissues. The former makes toremifene an excellent therapeutic agent against breast cancer. Although researchers are unclear of the precise mechanism by which toremifene kills breast cancer cells, it is known to compete with estrogen by binding to estrogen receptors, therefore limiting the effects of estrogen on breast tissue. Toremifene may also be involved in other anti-tumor activities affecting oncogene expression, promotion of apoptosis and growth factor secretion.
Toremifene is taken orally, and the recommended dose is usually 40 to 60 milligrams once a day, although larger doses are sometimes prescribed. If a dose is missed, patients should not double the next dosage. Instead, they should return to their regular schedule and contact their doctor.
Author Info: Sally C. McFarlane-Parrott, The Gale Group Inc., Gale, Detroit, Gale Encyclopedia of Cancer, 2002This feature is for informational purposes only and should not be used to replace the care and information received from your healthcare provider. Please consult a healthcare professional with any health concerns you may have.
Enter your symptoms in our Symptom Checker to find out possible causes of your symptoms. Go.
Enter any list of prescription drugs and see how they interact with each other and with other substances. Go.
Enter its color and shape information, and this tool helps you identify it. Go.
Find information on drug interactions, side effects, and more. Go.
Member access to health and insurance products and services at AARPhealthcare.com.
Members can get an instant quote with AARP® Dental Insurance administered by Delta Dental Insurance Company.
Members can save on eyewear with AARP® Vision Discounts provided by EyeMed.
Caregiving can be a lonely journey, but AARP offers resources that can help.