EMERGENCY: Help Seniors Affected by Hurricane Matthew. Donate Now


Grocery Coupons

Grocery Coupons

Members can print free savings coupons

Brain Health Center

Brain Health Center

Learn how to live smart and stay sharp

Amazon Kindle

Amazon Kindle

Members save on e-
readers and tablets

Caring for loved ones?

Caring for loved ones?

Find the resources you need

Drug Search
Enter a Drug Name Pick from Common Drugs
powered by Talix

Brand Name: Excedrin

Generic Name: apap/asa/caffeine

It is used to treat mild aches and pains
View All Brands

What is this medicine?

ACETAMINOPHEN; ASPIRIN; CAFFEINE (a set a MEE noe fen; AS pir in; KAF een) is a pain reliever. It is used to treat mild aches and pains. This medicine may help with arthritis, colds, headache (including migraine), muscle aches, menstrual cramps, sinusitis, and toothache.

What should I tell my health care provider before I take this medicine?

They need to know if you have any of these conditions:
  • anemia
  • anxiety or panic attacks
  • asthma
  • bleeding problems
  • child with chickenpox, the flu, or other viral infection
  • diabetes
  • gout
  • heart disease
  • high blood pressure
  • if you frequently drink alcohol containing drinks
  • kidney disease
  • liver disease
  • low level of vitamin K
  • lupus
  • smoke tobacco
  • stomach ulcers or other problems
  • trouble sleeping
  • an unusual or allergic reaction to acetaminophen, aspirin, caffeine, other medicines, foods, dyes or preservatives
  • pregnant or trying to get pregnant
  • breast-feeding

How should I use this medicine?

Take this medicine by mouth. Place one packet of powder on tongue and follow with plenty of liquid, or stir powder into a glass of water or other liquid. Follow the directions on the package or prescription label. You can take this medicine with or without food. If it upsets your stomach, take it with food. Take your medicine at regular intervals. Do not take your medicine more often than directed.

Talk to your pediatrician regarding the use of this medicine in children. Special care may be needed.

Patients over 65 years old may have a stronger reaction and need a smaller dose.

What if I miss a dose?

If you miss a dose, take it as soon as you can. If it is almost time for your next dose, take only that dose. Do not take double or extra doses.

What may interact with this medicine?

Do not take this medicine with any of the following medications:
  • MAOIs like Carbex, Eldepryl, Marplan, Nardil, and Parnate
  • methotrexate
  • other medicines with acetaminophen
  • probenecid

This medicine may also interact with the following medications:

  • alcohol
  • alendronate
  • bismuth subsalicylate
  • clozapine
  • flavocoxid
  • grapefruit juice
  • herbal supplements like feverfew, garlic, ginger, ginkgo biloba, horse chestnut
  • isoniazid
  • lithium
  • medicines for diabetes or glaucoma like acetazolamide, methazolamide
  • medicines for gout
  • medicines that stimulate or keep you awake
  • medicines that treat or prevent blood clots like enoxaparin, heparin, ticlopidine, warfarin
  • NSAIDs, medicines for pain and inflammation, like ibuprofen or naproxen
  • other aspirin and aspirin-like medicines
  • some cough and cold medicines like pseudoephedrine
  • varicella live vaccine

1 2

All visitors to should seek expert medical care and consult their own physicians for any specific health issues. Read this disclaimer in its entirety.
Note: This information is not intended to cover all possible uses, precautions, interactions, or adverse effects for this drug. If you have question about the drug(s) you are taking, check with your health care professional.
Symptom Search
Enter your symptoms in our Symptom Checker to find out possible causes of your symptoms. Go.
Drug Interaction Checker
Enter any list of prescription drugs and see how they interact with each other and with other substances. Go.
Pill Identifier
Enter its color and shape information, and this tool helps you identify it. Go.



Discounts & Benefits

From companies that meet the high standards of service and quality set by AARP.

Walgreens 1 discount membership aarp

Members can earn 50 points per $1 spent on select health & wellness products at Walgreens.

member benefit aarp hear usa

Members save 15% on easy listening devices and more at the HearUSA Hearing Shop.

Eye Med 4 Membership Benefit AARP Discount

Members save up to 60% on eye exams and 30% on glasses at Target Optical.

Membership Benefits Discounts Email Genius

Brain boost? Get AARP email for access to memory exercises & more that help you focus.