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Brand Name: Comtrex Cold & Cough Day Night

Generic Name: apap/chlorpheniramine/dextromethorphan/pe

It is used to treat the aches and pains, cough, fever, congestion, runny nose and sneezing of a cold
View All Brands
Tylenol Cold Head Congestion Nighttime Cool Burst, Comtrex Cold & Cough Day Night, Tylenol Cold Multi-Symptom Nighttime Cool Burst, Dimetapp Nighttime Flu, Comtrex Cold And Cough Nighttime, Theraflu Nighttime Severe Cold Caplets, Tylenol Children'S Plus Flu, Pediacare Children'S Flu Plus Apap, Tylenol Children'S Multi-Symptom Cold Plus, Triaminic Children'S Multi-Symptom Fever Cold, Tylenol Cold Multi-Symptom Nighttime, Tylenol Cold Head Congestion Day And Night, Dimetapp Nighttime Flu Reformulated Sep 2007, Theraflu Nighttime Severe Cold, Alka-Seltzer Plus Cold And Cough, Alka-Seltzer Plus Flu Reformulated Jan 2011, Robitussin Cough, Cold & Flu Nighttime, Pediacare Children'S Multi-Symptom Cold Plus Apap, Comtrex Nighttime Cold & Cough, Alka-Seltzer Plus Cough And Cold Liquigel Reformulated Aug 2011

What is this medicine?

ACETAMINOPHEN; CHLORPHENIRAMINE; DEXTROMETHORPHAN; PHENYLEPHRINE (a set a MEE noe fen; klor fen IR a meen; dex troe meth OR fan; fen il EF rin) is a combination of a pain reliever, an antihistamine, a cough suppressant, and a decongestant. It is used to treat the aches and pains, cough, fever, congestion, runny nose and sneezing of a cold. This medicine will not treat an infection.

What should I tell my health care provider before I take this medicine?

They need to know if you have any of these conditions:
  • asthma
  • cough that does not go away
  • cough with a lot of phlegm
  • diabetes
  • glaucoma
  • heart disease
  • high blood pressure
  • if you frequently drink alcohol containing drinks
  • liver disease
  • taken an MAOI like Carbex, Eldepryl, Marplan, Nardil, or Parnate in last 14 days
  • thyroid disease
  • trouble passing urine
  • an unusual or allergic reaction to acetaminophen, chlorpheniramine, dextromethorphan, phenylephrine, other medicines, foods, dyes, or preservatives
  • pregnant or trying to get pregnant
  • breast-feeding

How should I use this medicine?

Take this medicine by mouth. Follow the directions on the package label. Shake well before using. Use a specially marked spoon or container to measure each dose. Ask your pharmacist if you do not have one. Household spoons are not accurate. Take your medicine at regular intervals. Do not take it more often than directed.

Talk to your pediatrician regarding the use of this medicine in children. While this drug may be prescribed for children as young as 6 years old for selected conditions, precautions do apply.

What if I miss a dose?

If you miss a dose, take it as soon as you can. If it is almost time for your next dose, take only that dose. Do not take double or extra doses.

What may interact with this medicine?

Do not take this medicine with any of the following medications:
  • cocaine
  • ergot alkaloids like dihydroergotamine, ergonovine, ergotamine, methylergonovine
  • MAOIs like Carbex, Eldepryl, Marplan, Nardil, and Parnate
  • stimulant medicines like dextroamphetamine and others

This medicine may also interact with the following medications:

  • alcohol
  • bretylium
  • furazolidone
  • imatinib
  • isoniazid
  • linezolid
  • mecamylamine
  • medicines for anxiety or sleep
  • medicines for blood pressure like atenolol, clonidine, doxazosin, methyldopa, metoprolol
  • medicines for chest pain like isosorbide dinitrate, nitroglycerin
  • medicines for enlarged prostate like tamsulosin
  • medicines for sleep during surgery
  • other medicines for cold, cough or allergy
  • other medicines with acetaminophen
  • procarbazine
  • reserpine
  • St. John's Wort

What should I watch for while using this medicine?

Tell your doctor or healthcare professional if your symptoms do not start to get better or if they get worse. Let your doctor know if you have pain, nasal congestion, or cough that gets worse or lasts for more than 7 days. Call your doctor if you have a fever that gets worse or lasts for more than 3 days. If you have a cough that lasts more than 2 days, if your cough comes back, or if it occurs with a fever, rash, headache, nausea, or vomiting see your doctor.

You may get drowsy or dizzy. Do not drive, use machinery, or do anything that needs mental alertness until you know how this medicine affects you. Do not stand or sit up quickly, especially if you are an older patient. This reduces the risk of dizzy or fainting spells. Alcohol may interfere with the effect of this medicine. Avoid alcoholic drinks.

Do not take other medicines that contain acetaminophen with this medicine. Always read labels carefully. If you have questions, ask your doctor or pharmacist.

If you take too much acetaminophen get medical help right away. Too much acetaminophen can be very dangerous and cause liver damage. Even if you do not have symptoms, it is important to get help right away.

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All visitors to AARP.org should seek expert medical care and consult their own physicians for any specific health issues. Read this disclaimer in its entirety.
Note: This information is not intended to cover all possible uses, precautions, interactions, or adverse effects for this drug. If you have question about the drug(s) you are taking, check with your health care professional.
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