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Brand Name: Wellbutrin

Generic Name: bupropion

It is used to treat depression.
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What is this medicine?

Wellbutrin (byoo PROE pee on) is used to treat depression.

What should I tell my health care provider before I take this medicine?

They need to know if you have any of these conditions:
  • an eating disorder, such as anorexia or bulimia
  • bipolar disorder or psychosis
  • diabetes or high blood sugar, treated with medication
  • heart disease, previous heart attack, or irregular heart beat
  • head injury or brain tumor
  • high blood pressure
  • kidney or liver disease
  • seizures
  • suicidal thoughts or a previous suicide attempt
  • Tourette's syndrome
  • weight loss
  • an unusual or allergic reaction to bupropion, other medicines, foods, dyes, or preservatives
  • breast-feeding
  • pregnant or trying to become pregnant

How should I use this medicine?

Take this medicine by mouth with a glass of water. Follow the directions on the prescription label. You can take it with or without food. If it upsets your stomach, take it with food. Take your medicine at regular intervals. Do not take your medicine more often than directed. Do not stop taking this medicine suddenly except upon the advice of your doctor. Stopping this medicine too quickly may cause serious side effects or your condition may worsen.

A special MedGuide will be given to you by the pharmacist with each prescription and refill. Be sure to read this information carefully each time.

Talk to your pediatrician regarding the use of this medicine in children. Special care may be needed.

What if I miss a dose?

If you miss a dose, take it as soon as you can. If it is less than four hours to your next dose, take only that dose and skip the missed dose. Do not take double or extra doses.

What may interact with this medicine?

Do not take this medicine with any of the following medications:
  • linezolid
  • MAOIs like Azilect, Carbex, Eldepryl, Marplan, Nardil, and Parnate
  • methylene blue (injected into a vein)
  • other medicines that contain bupropion like Zyban

This medicine may also interact with the following medications:

  • alcohol
  • certain medicines for anxiety or sleep
  • certain medicines for blood pressure like metoprolol, propranolol
  • certain medicines for depression or psychotic disturbances
  • certain medicines for HIV or AIDS like efavirenz, lopinavir, nelfinavir, ritonavir
  • certain medicines for irregular heart beat like propafenone, flecainide
  • certain medicines for Parkinson's disease like amantadine, levodopa
  • certain medicines for seizures like carbamazepine, phenytoin, phenobarbital
  • cimetidine
  • clopidogrel
  • cyclophosphamide
  • furazolidone
  • isoniazid
  • nicotine
  • orphenadrine
  • procarbazine
  • steroid medicines like prednisone or cortisone
  • stimulant medicines for attention disorders, weight loss, or to stay awake
  • tamoxifen
  • theophylline
  • thiotepa
  • ticlopidine
  • tramadol
  • warfarin

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All visitors to should seek expert medical care and consult their own physicians for any specific health issues. Read this disclaimer in its entirety.
Note: This information is not intended to cover all possible uses, precautions, interactions, or adverse effects for this drug. If you have question about the drug(s) you are taking, check with your health care professional.
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