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Adrenal Cortical Carcinoma

What Is Adrenal Cortical Carcinoma?

Adrenal cortical carcinoma (ACC) is a rare disease. It is caused by a cancerous growth in the adrenal cortex, which is the outer layer of the adrenal glands. The adrenal glands lie on top of the kidneys. They play an important role in the endocrine system, which is the system that makes and regulates hormones. ACC is also known as adrenocortical carcinoma

The adrenal cortex makes hormones that regulate metabolism and blood pressure. It also produces cortisol and the male hormones known as androgens. ACC may trigger excessive production of these hormones.

Types of Adrenal Cortical Carcinomas

There are two types of adrenal cortical carcinomas.

Functioning tumors increase the production of adrenal hormones. With this type of tumor, large amounts of cortisol, testosterone, and aldosterone are usually found in the body. (Aldosterone is a hormone that regulates blood pressure.)

Nonfunctioning tumors do not increase the adrenal glands’ hormone production.

Most tumors on the adrenal glands are not cancerous. Only 5 to 10 percent of adrenal tumors are malignant.

What Causes an Adrenal Cortical Carcinoma?

The causes of primary ACC are unknown. However, ACC can also be a secondary cancer. A secondary cancer is what happens when another form of cancer spreads to the adrenal glands.

Who Is at Risk for an Adrenal Cortical Carcinoma?

Scientists have identified a number of risk factors for ACC. You may be more at risk if you:

  • are female
  • are a child under age 5
  • are between the ages of 40 and 50
  • have a hereditary disease that affect the adrenal glands
  • have another form cancer that is aggressive

ACC is a rare cancer. Just because you have one or more risk factors does not mean you will get ACC.

What Are the Symptoms of an Adrenal Cortical Carcinoma?

The symptoms of a functioning tumor depend on what hormones it is producing.

Testosterone and other androgens:

  • increased facial and body hair, particularly in females
  • deepened voice in females

Estrogen:

  • early signs of puberty in children
  • enlarged breast tissue in males

Aldosterone:

  • weight gain
  • high blood pressure

Cortisol:

  • high blood sugar and pressure
  • muscle weakness in the legs
  • bruising in the body
  • excessive weight gain in chest and abdomen

Both functioning and nonfunctioning tumors can cause abdominal pain if they become enlarged. Nonfunctioning tumors may not produce any hormonal changes or cause specific symptoms

BE AWARE: Cushing’s syndrome is a condition caused by cortisol producing adrenal tumors. Although ACC can cause Cushing’s, most of the tumors that cause it are benign. If you have Cushing’s it does not mean you have cancer.

Diagnosing an Adrenal Cortical Carcinoma

To diagnose ACC, your doctor will perform a physical exam. You may also need lab tests to check your hormone levels. This could require collecting your saliva, blood, and urine.

Your doctor might also want to use imaging tests to look for a tumor on your adrenal glands. These tests could include:

  • magnetic resonance imaging (MRI)
  • computed tomography (CT) scan
  • positron emission tomography (PET) scan

If a tumor is found, a small piece of tissue might be taken for study. This is called a biopsy. A biopsy allows your doctor to see if tumor cells are cancerous or benign. Most adrenal tumors are non-cancerous.

Treating an Adrenal Cortical Carcinoma

Your doctor will develop a treatment plan based on your condition, sex, age and overall physical health. He may also stage your cancer. Staging tells your doctor how advanced your cancer is. This can help determine the right treatment.

Tumor stages are defined as follows:

  • Stage 1 tumors are small tumors (less than 5 centimeters) that are still within the tissues.
  • Stage 2 tumors are large tumors (greater than 5 centimeters) that are still within the tissues.
  • Stage 3 tumors are tumors of any size that have spread to nearby lymph nodes and fatty tissue.
  • Stage 4 tumors are tumors of any size that have spread to other organs and tissues.).

Depending on the stage of your ACC, a variety of treatments are available.

Chemotherapy uses drugs to kill cancer cells in the body. These drugs may be taken by mouth or administered through the veins.

Surgery can remove the adrenal gland and surrounding tissue, if necessary.

Radiation can be used to kill cancer cells. There are two types of radiation therapy. External radiation therapy is applied from the outside of your body. Internal therapy applies radioactive substances directly to the tumor. Radiation may be put in place with catheters, needles, or wires.

Biologic therapy uses your own immune system and body to destroy the cancer.

Prognosis: What Is to Be Expected in the Long Term?

The stage of your cancer may influence how well treatments work. Your doctor will request follow-up visits in order to check your cancer’s response to treatment. Sometimes a tumor may return, and you may need further treatment.

Your health will also be monitored for other potential problems caused by ACC. The hormone changes caused by functional tumors can cause severe symptoms. Fixing these problems can become a main objective of treatment.


Content licensed from:

Written by: Brindles Lee Macon
Published on: Jul 16, 2012on: Jan 14, 2016

This feature is for informational purposes only and should not be used to replace the care and information received from your health care provider. Please consult a health care professional with any health concerns you may have.
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