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Anticoagulant and Antiplatelet Drugs

Overview

Anticoagulants and antiplatelet drugs eliminate or reduce the risk of blood clots. They’re often called blood thinners, but these medications don’t really thin your blood. Instead, they help prevent or break up dangerous blood clots that form in your blood vessels or heart. Without treatment, these clots can block your circulation and lead to a heart attack or stroke.

What these drugs do

Both antiplatelets and anticoagulants work to prevent clots in your blood vessels, but they work in different ways.

Antiplatelets interfere with the binding of platelets, or the process that actually starts the formation of blood clots.

Anticoagulants interfere with the proteins in your blood that are involved with the coagulation process. These proteins are called factors. Different anticoagulants interfere with different factors to prevent clotting.

List of anticoagulants and antiplatelets

There are many anticoagulants, including:

Common antiplatelets include:

  • clopidogrel (Plavix)
  • ticagrelor (Brilinta)
  • prasugrel (Effient)
  • dipyridamole
  • dipyridamole/aspirin (Aggrenox)
  • ticlodipine (Ticlid)
  • eptfibatide (Integrilin)

Uses

Your doctor may recommend an anticoagulant or antiplatelet drug if you have one or more of the following conditions. Each of these can cause blood to pool in your vessels, which can lead to clot formation:

  • heart disease
  • problems with blood circulation
  • abnormal heartbeat
  • congenital heart defect

Your doctor may also prescribe one of these drugs if you’ve had heart valve surgery.

If you take warfarin, you will have regular blood tests called international normalized ratio (INR) tests. The results help your doctor decide if the medication is at the right level in your body. Your doctor may also run other tests if you take different medications.  

Side effects and risks

There are side effects associated with anticoagulant or antiplatelet drugs, and some can be serious. Call your doctor if you notice any of the following symptoms while taking any anticoagulant or antiplatelet drugs:

  • increased bruising
  • red or pink colored urine
  • stools that are bloody or look like coffee grounds
  • more bleeding than normal during your menstrual period
  • purple toes
  • pain, change in temperature, or blackish areas in your fingers, toes, hands, or feet

Because of the side effects of these types of drugs, certain people have an increased risk of complications when using them. Some people shouldn’t use them at all. If you have bleeding disorder, diabetes, high blood pressure, balance problems, congestive heart failure, or liver or kidney problems, talk to your doctor. Warfarin may increase your risk of complications from these conditions. If you are pregnant or breastfeeding, do not use warfarin. Doing so can increase the risk of fetal death and harm to your baby.

Some drugs and dietary supplements can further increase your risk of bleeding, so tell your doctor about all of the prescription and over-the-counter products you take.

Tips

While you take any of these drugs, follow these tips to help keep you healthy and safe:

  • Tell all of your healthcare providers that you’re taking an anticoagulant or antiplatelet, as well as any other drugs.
  • Be sure to wear an identification bracelet.
  • Avoid sports and other activities that might cause injury. It may be difficult for your body to stop bleeding or to clot normally.
  • Talk to your doctor if you plan on having surgery or certain dental procedures. These may put you at risk of bleeding that is difficult to stop. Your doctor may recommend that you stop taking your antiplatelet or anticoagulant drugs for a period before and after the procedure.

Talk to your doctor

The risks and side effects of these drugs can be serious. When taking anticoagulant and antiplatelet drugs, follow the instructions your doctor’s instructions and call your doctor if you miss a dose.


Content licensed from:

Written by: Tricia Kinman
Medically reviewed on: Dec 01, 2016: Aleah Rodriguez, PharmD

This feature is for informational purposes only and should not be used to replace the care and information received from your health care provider. Please consult a health care professional with any health concerns you may have.
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