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Dermatomyositis is a rare inflammatory disease. Common symptoms of dermatomyositis include a distinctive skin rash, muscle weakness, and inflammatory myopathy, or inflamed muscles. It’s one of only three known inflammatory myopathies. Dermatomyositis can affect both adults and children. There’s no cure for this condition, but symptoms can be managed.

What Causes Dermatomyositis?

The exact cause of dermatomyositis isn’t known. However, it has many similarities to an autoimmune disease. An autoimmune disease occurs when your body’s disease-fighting cells, called antibodies, attack your healthy cells. Having a compromised immune system may also contribute. For example, having a viral infection or cancer may compromise your immune system and lead to the development of dermatomyositis.

Who Is at Risk for Developing Dermatomyositis?

Anyone can develop dermatomyositis. However, according to the Mayo Clinic, it’s most common in adults between the ages of 40 and 60 and children between the ages of 5 and 15. The disease affects women more often than men.

What Are the Symptoms of Dermatomyositis?

In most cases, the first symptom is a distinctive skin rash on the face, chest, nails, or elbows. The rash is patchy and usually a bluish-purple color.

You may also have muscle weakness that gets worse over weeks or months. This muscle weakness usually starts in your neck, arms, or hips and can be felt on both sides of your body.

Other symptoms you might experience are:

  • muscle pain
  • muscle tenderness
  • problems swallowing
  • lung problems
  • hard calcium deposits underneath the skin, which is mostly seen in children
  • fatigue
  • unintentional weight loss
  • fever

There is a subtype of dermatomyositis that includes the rash but not muscle weakness. This is known as amyopathic dermatomyositis.

Diagnosis of Dermatomyositis

Your doctor will ask you questions about your symptoms and medical history and perform a physical exam. Dermatomyositis is an easier inflammatory muscle disease to diagnose because of the rash associated with it.

Your doctor may also order:

  • an MRI to look for abnormal muscles
  • an electromyography (EMG) to record electrical impulses that control your muscles
  • a blood analysis to check your levels of muscle enzymes and autoantibodies, which are antibodies that attack normal cells
  • a muscle biopsy to look for inflammation and other problems associated with the disease in a sample of muscle tissue
  • a skin biopsy to look for changes caused by the disease in a skin sample

Treatment for Dermatomyositis

There’s no cure for dermatomyositis. Treatment can improve the condition of your skin and muscle weakness. Available treatments include medication, physical therapy, and surgery. The most common treatment is corticosteroids.

Corticosteroid medications, such as prednisone, are the preferred method of treatment in most cases. You can take them by mouth or apply them to your skin. Corticosteroids lower the response of your immune system, which reduces the amount of inflammation-causing antibodies.

Corticosteroids shouldn’t be used for long periods of time because of their potential side effects. Your doctor will most likely start you on a high dose and then gradually lower it.

If corticosteroids alone don’t improve your symptoms, your doctor might prescribe other medications to suppress your immune system.

Corticosteroid-sparing medications are used to reduce the side effects of corticosteroids. Drugs such as azathioprine and methotrexate may be used if your case is advanced or if you have any complications.

Intravenous Immunoglobulin (IVIG)

You’re producing antibodies that target your skin and muscles if you have dermatomyositis. Intravenous immunoglobulin (IVIG) uses healthy antibodies to block these antibodies. IVIG consists of a mixture of antibodies that have been collected from thousands of healthy people who have donated their blood. These antibodies are given to you through an IV.

Additional Treatments

Your doctor might suggest additional treatments, such as:

  • physical therapy that improves and preserves your muscle strength along with preventing loss of muscle tissue
  • antimalarial medications for a persistent rash
  • surgery to remove calcium deposits
  • medications to help with pain

Possible Complications of Dermatomyositis

The muscle weakness and skin problems linked with dermatomyositis can cause a number of problems. Some common complications are:

  • skin ulcers
  • gastric ulcers
  • difficulty breathing
  • lung infections
  • problems swallowing
  • malnutrition
  • weight loss


There’s no cure for dermatomyositis, but your symptoms can be treated. Your doctor will create a treatment plan for you that will help you manage your symptoms. 

Content licensed from:

Written by: Carmella Wint and Marijane Leonard
Published on: Jul 25, 2012
Medically reviewed on: Nov 18, 2015: [Ljava.lang.Object;@6a9adffc

This feature is for informational purposes only and should not be used to replace the care and information received from your health care provider. Please consult a health care professional with any health concerns you may have.
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