Diseases & Conditions A - Z
powered by Talix

Nephrogenic Diabetes Insipidus (NDI)

What Is Nephrogenic Diabetes Insipidus?

Nephrogenic Diabetes Insipidus (NDI) is a rare disorder that occurs when the kidneys are unable to concentrate urine. In most people, the body balances intake of fluids with urine excretion. However, people with NDI produce excessive amounts of urine (a condition known as polyuria), which result in insatiable thirst (polydipsia). This balance is regulated by a hormone called vasopressin or antidiuretic hormone (ADH).

Waste and excess water in the blood are filtered through the kidneys, which store liquid waste in the bladder. When fluid intake is low, levels of ADH increase and signal the kidneys to make less urine. Conversely, when fluid intake is high, ADH levels decrease and cause the kidneys to create more urine.

NDI can be acquired through chronic disease or use of certain medications, or inherited (caused by genetic mutations passed down through families). These conditions and mutations interfere with the normal functioning of ADH.

The symptoms of NDI make diagnosis difficult in childhood. To help with diagnosis, doctors use urinary and blood tests. Most cases of NDI are treated with medications.

What Causes Nephrogenic Diabetes Insipidus?

The cause of NDI can be acquired (through drug use or another disease) or genetic (inherited from parents).

Genetic NDI is caused by a mutation in one of two genes: AVPR2 or AQP2. Mutations are mistakes or damage that causes a change in the genes of a person. According to the National Library of Medicine (NLM), 90 percent of cases of inherited NDI are due to mutations in the AVPR2 gene. (NLM, 2010)

Mutations of the AVPR2 gene are classified as X-linked recessive disorders. This means that the gene defect is on the X chromosome. Because males have only one X chromosome, if they inherit an X chromosome with the gene mutation, they will have the disease. Because women have two X chromosomes, they will only acquire the disease if both X chromosomes have the gene mutation.

A smaller percentage of genetic NDI is caused by mutations in the AQP2 gene, which is primarily autosomal recessive. This means a person must receive a copy of the abnormal gene from each parent in order to develop NDI. In very rare cases, AQP2 is autosomal dominant, meaning that a person only receives one copy of the mutated gene.

NDI can also be acquired. Most acquired forms are from drug use. Medical conditions that affect the minerals of the body or damage the organs can also be linked to NDI.

Drugs that can cause acquired NID include:

  • long-term use of lithium, used to treat bipolar disorder and other mental conditions
  • demeclocycline, an antibiotic
  • rifampin, used to treat tuberculosis
  • methicillin, an antibiotic
  • foscarnet, used to treat herpes

Medical conditions that can cause acquired NID include:

  • primary renal disease
  • polycystic kidney disease ureteral obstruction, in which cysts grow on the kidneys and create a block anywhere in the urinary tract
  • hypercalcemia, too much calcium in the blood
  • hypokalemia, too low potassium in the blood

What Are the Symptoms of Nephrogenic Diabetes Insipidus?

The symptoms of NDI vary with age. Infants are severely affected, but symptoms can resemble many other disorders. As children age, symptoms begin to become more recognizable. If a diagnosis is not made, symptoms can become severe enough to cause death.

Symptoms seen in infants can include:

  • excessive wet diapers
  • vomiting
  • recurring fevers of unknown origin
  • constipation

Symptoms in young children can include:

  • bedwetting
  • difficulties in toilet training
  • failure to thrive
  • mental confusion caused by dehydration

Older children and teenagers can display symptoms that include:

  • high urine output
  • disturbed sleep and easy fatigue from night urination
  • anorexia (low weight) from preferring water to food
  • failure to thrive

Adults display the most common symptoms, which include:

  • excessive thirst
  • excessive urination
  • frequent urination during the night
  • increased sodium in the blood

Rare and fatal symptoms include:

  • death due to hypovolemic shock (when severe dehydration results in there not being enough blood for your heart to pump)
  • hypernatremic seizure (seizures caused by extreme high levels of sodium in the blood)

How Is Nephrogenic Diabetes Insipidus Diagnosed?

Early diagnosis of NDI is important in preventing life-threatening complications. Tests are ultimately looking for low fasting urine osmolality in the presence of severe water depletion.

Types of urine testing include:

  • polyuria test, which measures 24-hour urine output by direct collection
  • first morning test, which measures the specific gravity (density) of urine as well as any chemicals present
  • measurement of pH, sodium potassium, chloride etc.

Other tests for NID include:

  • MRI etiology
  • renal sonography, to rule out renal disorders and look for long-term damage
  • blood test to measure levels of sodium, potassium, chloride, urea, creatine, etc.

A water deprivation test (WDT) can be potentially life threatening and is done only under knowledgeable medical teams. The test has the patient refrain from drinking water to see if there is any change in the amount of urine released.

How Is Nephrogenic Diabetes Insipidus Treated?

Treatment focuses upon regulating the thirst mechanism and amount of urine released. Medication can be used for successful treatment.

Medications for NID include:

  • bendroflumethiazide (bendrofluazide) to reduce thirst and night urination frequency
  • desmopressin to treat genetic NID (Note: high doses are usually required)
  • drugs to regulate water excretion (thiazide, amiloride, indomethacin etc.)

Other treatment options for NID include:

  • intravenous hydration in cases of severe dehydration
  • diet low in sodium
  • intravenous replenishment of five percent glucose

What Is the Outlook for Nephrogenic Diabetes Insipidus?

Children who go untreated for NDI can fail to thrive. In severe cases, they may experience mental retardation from the body’s constant dehydration.

Without treatment, NDI can lead to death from dehydration complications. The prognosis is good for those who receive treatment, and medications can help to keep health stable.

Content licensed from:

Written by: Lydia Krause
Published on: Jul 16, 2012
Medically reviewed on: Dec 15, 2016: University of Illinois-Chicago, School of Medicine

This feature is for informational purposes only and should not be used to replace the care and information received from your health care provider. Please consult a health care professional with any health concerns you may have.
Symptom Search
Enter your symptoms in our Symptom Checker to find out possible causes of your symptoms. Go.
Drug Interaction Checker
Enter any list of prescription drugs and see how they interact with each other and with other substances. Go.
Pill Identifier
Enter its color and shape information, and this tool helps you identify it. Go.
Drugs A-Z
Find information on drug interactions, side effects, and more. Go.



Discounts & Benefits

From companies that meet the high standards of service and quality set by AARP.

Member Benefits AT&T Wireless Cell Phone

Members save 10% on the monthly service charge of qualified AT&T wireless plans.

Member Benefit AARP Regal 2

Members pay $9.50 for Regal ePremiere Tickets purchased online.

Walgreens 1 discount membership aarp

Members earn points on select Walgreens-brand health and wellness products.

Member Benefits

Join or renew today! Members receive exclusive member benefits & affect social change.