Get exclusive member benefits & effect social change. Join Today
Factor V deficiency is also known as Owren’s disease or parahemophilia. It’s a very rare blood clotting disorder that results in slow or prolonged blood clotting after an injury or surgery. Factor V, or proaccelerin, is a protein made in your liver that helps convert prothrombin into thrombin. This is an important step in the blood clotting process. Your blood clots may be too weak to stop you from bleeding if you don’t have enough factor V or if it doesn’t work properly.
Factor V deficiency may occur at the same time as factor VIII deficiency, producing more severe blood clotting problems. A combination of factor V and factor VIII deficiencies is considered to be a separate disorder.
Factor V is one of about 13 clotting factors responsible for normal blood coagulation. Blood clotting occurs in stages:
Secondary hemostasis doesn’t occur properly if you have factor V deficiency. This results in prolonged bleeding.
Factor V deficiency may be inherited or acquired after birth. Hereditary factor V deficiency is extremely rare. It’s caused by a recessive gene, which means that you have to inherit the gene from both of your parents in order to show symptoms. There are only 105 documented cases of inherited factor V deficiency in the world.
Acquired factor V deficiency may be caused by certain medications, underlying medical conditions, or an autoimmune reaction. Conditions that might affect factor V include:
The symptoms of factor V deficiency are generally very mild. Factor V levels can be as low as 10-20 percent of normal and your blood will still clot, although a bit more slowly.
In cases of severe factor V deficiency, the symptoms may include:
Many people who have this condition are diagnosed when doctors run blood coagulation tests before surgery. Common lab tests for factor V include the following:
Since factor V deficiency is generally mild, treatment is mostly precautionary. Your doctor may recommend you use desmopressin (DDAVP) before surgery or dental procedures. DDAVP is a nasal spray that temporarily boosts your factor levels. In the event of a severe bleeding episode, you may be given infusions of fresh frozen plasma (FFP) and blood platelets to replace your missing blood clotting factor.
Factor V deficiency is relatively manageable compared to other blood clotting disorders. Most people who have this condition need treatment only after surgery or a very serious injury. People who have this condition usually live normal lives and only bleed a little bit longer than people who have blood that coagulates normally.
Written by: Janet Barwell
Published on: Jul 16, 2012on: Jul 21, 2017
Enter your symptoms in our Symptom Checker to find out possible causes of your symptoms. Go.
Enter any list of prescription drugs and see how they interact with each other and with other substances. Go.
Enter its color and shape information, and this tool helps you identify it. Go.
Find information on drug interactions, side effects, and more. Go.
From companies that meet the high standards of service and quality set by AARP.
Members save 10% on the monthly service charge of qualified AT&T wireless plans.
Members pay $9.50 for Regal ePremiere Tickets purchased online.
Members earn points on select Walgreens-brand health and wellness products.
Join or renew today! Members receive exclusive member benefits & affect social change.