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Narcolepsy is a lifelong nervous system disorder that causes abnormal sleep that can affect a person’s quality of life. It is a rare condition estimated to affect about 1 out of every 2,000 people. The symptoms of narcolepsy usually begin between the ages of 10 and 25 years, although the condition is often not recognized right away.
Narcolepsy causes significant daytime drowsiness and sleep attacks. In a majority of cases, it also causes unexpected and temporary loss of muscle control, known as cataplexy. Narcolepsy isn’t a deadly disease by itself, but episodes can lead to accidents, injuries, or life-threatening situations.
There are two types of narcolepsy: Type 1 is narcolepsy with cataplexy, and Type 2 is narcolepsy without cataplexy. Type 1 is the most common. Cataplexy, especially in children, can be mistaken for seizure activity.
Sleep experts attribute symptoms of narcolepsy to poorly regulated rapid eye movement (REM) sleep. How often and how intensely symptoms occur can vary. Common symptoms can include:
Significant daytime sleepiness: Excessive daytime drowsiness is often the first symptom of narcolepsy. It makes it difficult to function properly during the day.
Cataplexy: This is the sudden, temporary loss of muscle tone. It can be triggered by intense emotions. These may include excitement, laughter, anger, and fear. The frequency of cataplexy varies. Some people may have it several times per day. Other people may experience it a few times per year.
Hallucinations when falling asleep: Hallucinations can also occur in people with narcolepsy. This is because dreaming is typically part of REM sleep. If dreams occur when you’re partially awake, they may seem like reality.
Sleep paralysis: This is an inability to move or speak while falling asleep, sleeping, or waking. Episodes last only a few minutes. Sleep paralysis mimics the paralysis seen during REM sleep. It does not affect eye movements or the ability to breathe. It can even occur in people who don’t have narcolepsy.
The exact cause of narcolepsy is unknown. However, most people with narcolepsy and cataplexy have a decreased amount of a brain protein called hypocretin. One of the functions of hypocretin is regulating your sleep-wake cycles.
Scientists think low hypocretin levels may be caused by several factors. A gene mutation has been identified that causes low levels of hypocretin. It’s believed that this hereditary deficiency, along with an immune system that attacks healthy cells, contributes to narcolepsy. Other factors such as stress, exposure to toxins, and infection also may play a role.
Normal sleep occurs in five stages and in cycles. As the sleep cycle begins, we move from light sleep to deep sleep, then into REM sleep, when dreaming and muscle paralysis occur. It takes about 70 to 90 minutes to reach the first cycle of REM sleep. The longer we stay asleep, the more time we spend in REM, and the less time we spend in deep sleep. Scientists believe adequate REM sleep is necessary for our survival.
People with narcolepsy can suddenly fall asleep, lose muscle tone, and begin to dream. This may happen no matter what they’re doing or what time of day it is. When this happens, their REM sleep occurs inappropriately and spontaneously. The symptoms of REM sleep can happen all at once.
The Center for Narcolepsy at the Stanford University School of Medicine reports that one in every 2,000 Americans has narcolepsy. If you have excessive daytime sleepiness or one of the other common symptoms of narcolepsy, talk to your doctor. Daytime sleepiness is common in many types of sleep disorders. Your doctor will ask you about your medical history and perform a physical exam. They’ll look for a history of excessive daytime drowsiness and episodes of sudden loss of muscle tone. The doctor will usually require a sleep study and several other tests to determine the correct diagnosis.
Some common sleep evaluations include the following:
Narcolepsy has no cure. It’s a chronic condition that lasts a lifetime. The goal of treatment, then, is to control symptoms and improve daytime functioning. Stimulants, lifestyle adjustments, and avoiding hazardous activities are all important in treating this disorder.
There are several classes of medications used to treat narcolepsy. For example:
Here are some steps you can take to make living with narcolepsy easier and safer:
Living with narcolepsy can be challenging. It can be stressful to have episodes of excessive sleepiness, and it’s possible to injure yourself or others during an episode. By obtaining the correct diagnosis, working with your doctor to find the best treatment for you, and following the above tips, you can manage your narcolepsy and continue living a healthy life.
Written by: Verneda Lights and Elizabeth Boskey, PhD
Medically reviewed on: Apr 03, 2017: Judith Marcin, MD
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