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Serum Hemoglobin Test

What Is a Serum Hemoglobin Test?

A serum hemoglobin test measures the amount of free-floating hemoglobin in your blood serum. Serum is the liquid that is left over from your blood plasma when the red blood cells and the clotting elements have been removed. Hemoglobin is a type of oxygen-carrying protein found in your blood.

Most of the hemoglobin in your blood is inside your red blood cells. A smaller percentage of the hemoglobin is located in your serum. This is called free hemoglobin. The serum hemoglobin test measures this free hemoglobin.

Doctors usually use this test to diagnose or monitor hemolytic anemia. If you have this type of anemia, your red blood cells break down too quickly. This leads to higher-than-normal levels of free hemoglobin in your blood.

The test is sometimes called a blood hemoglobin test.

The Serum Hemoglobin Test

When you arrive for a serum hemoglobin test, your doctor or a nurse will use a small needle to draw a sample of blood from your arm or hand. This sample is then sent to a laboratory for analysis.

Why Doctors Perform a Serum Hemoglobin Test

Your doctor may order a serum hemoglobin test if you are exhibiting symptoms of hemolytic anemia. This condition occurs when your red blood cells break down rapidly and your bone marrow cannot replace them quickly enough.

Your doctor may also order this test if you have already been diagnosed with hemolytic anemia. In this case, the test can help your doctor monitor your condition.

Hemolytic Anemia

There are two types of hemolytic anemia.

If you have extrinsic hemolytic anemia, your body produces normal red blood cells. However, they are destroyed too quickly because of an infection, an autoimmune disorder, or a particular type of cancer.

If you have intrinsic hemolytic anemia, your red blood cells themselves are defective and naturally break down quickly. Sickle cell anemia, thalassemia, congenital spherocytic anemia, and G6PD deficiency are all conditions that can lead to hemolytic anemia.

Both types of hemolytic anemia cause the same symptoms. However, you may have additional symptoms if your anemia is caused by an underlying condition.

In the early stages of hemolytic anemia, you may feel:

  • weak
  • dizzy
  • confused
  • grumpy
  • tired

You may also experience headaches.

As the condition progresses, your symptoms will become more serious. Your skin may become yellow or pale and the whites of your eyes may become blue or yellow. Other symptoms may include:

  • brittle nails
  • heart issues (an increased heart rate or heart murmur)
  • dark urine
  • an enlarged spleen
  • an enlarged liver
  • tongue soreness

Serum Hemoglobin Test Results

Normal Results

Serum hemoglobin is measured in grams of hemoglobin per deciliter of blood (g/dL). For females, the normal range is 12.3 to 15.3 g/dL. For males, the normal range is 14.0 to 17.5 g/dL.

Abnormal Results

Elevated levels of hemoglobin in your serum generally indicate hemolytic anemia. Conditions that can cause red blood cells to break down abnormally include, but are not limited to:

  • sickle cell anemia (a genetic disorder that causes your red blood cells to be rigid and unusually shaped)
  • G6PD deficiency (when your body does not make enough of the enzyme that produces red blood cells)
  • hemoglobin C disease (a genetic disorder that leads to the production of abnormal hemoglobin)
  • thalassemia (a genetic disorder that affects your body’s ability to produce normal hemoglobin)
  • congenital spherocytic anemia (a disorder of your red blood cell membranes)

If the results of your test are abnormal, your doctor will probably perform more tests to determine exactly what is causing hemolytic anemia. These additional tests may be simple blood and/or urine tests, or may involve testing your bone marrow.

Risks of the Serum Hemoglobin Test

The only risks involved in this test are those always associated with a blood draw. For example, you will probably experience slight pain when the needle is inserted to draw your blood. You might bleed a little when the needle is removed or develop a small bruise in the area.

Rarely, a blood draw may have more serious consequences, such as excessive bleeding, fainting, or an infection at the puncture site.


Content licensed from:

Written by: Gretchen Holm
Published on: Jun 01, 2012
Medically reviewed on: Jan 27, 2016: Deborah Weatherspoon, Ph.D, MSN, RN, CRNA

This feature is for informational purposes only and should not be used to replace the care and information received from your health care provider. Please consult a health care professional with any health concerns you may have.
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