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Generic Name: clofarabine

It reduces the growth of cancer cells and can suppress the immune system
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What is this medicine?

CLOFARABINE (kloe FAR a been) is a chemotherapy drug. It reduces the growth of cancer cells and can suppress the immune system. It is used for treating leukemia.

What should I tell my health care provider before I take this medicine?

  • bleeding problems
  • infection (especially a virus infection such as chickenpox, cold sores, or herpes)
  • kidney disease
  • liver disease
  • an unusual or allergic reaction to clofarabine, other medicines, foods, dyes, or preservatives
  • pregnant or trying to get pregnant
  • breast-feeding

How should I use this medicine?

This drug is given as an infusion into a vein. It is given in a hospital or clinic by a specially trained health care professional.

Talk to your pediatrician regarding the use of this medicine in children. While this drug may be prescribed for children as young as 1 year of age for selected conditions, precautions do apply.

What if I miss a dose?

It is important not to miss a dose. Call your doctor or health care professional if you are unable to keep an appointment.

What may interact with this medicine?

  • medicines for blood pressure, heart disease, irregular heart beat
  • vaccines
  • medicines that treat or prevent blood clots like warfarin

Talk to your doctor or health care professional before taking any of these medicines:

  • acetaminophen
  • aspirin
  • ibuprofen
  • naproxen
  • ketoprofen

What should I watch for while using this medicine?

This drug may make you feel generally unwell. This is not uncommon, as chemotherapy can affect healthy cells as well as cancer cells. Report any side effects. Continue your course of treatment even though you feel ill unless your doctor tells you to stop.

In some cases, you may be given additional medicines to help with side effects. Follow all directions for their use.

This drug can cause vomiting and diarrhea which may lead to dehydration. Signs and symptoms of dehydration include dizziness, lightheadedness, fainting spells, or decreased urine output. If you notice any of these symptoms, call your doctor immediately.

Call your doctor or health care professional for advice if you get a fever, chills or sore throat, or other symptoms of a cold or flu. Do not treat yourself. This drug decreases your body's ability to fight infections. Try to avoid being around people who are sick.

This medicine may increase your risk to bruise or bleed. Call your doctor or health care professional if you notice any unusual bleeding.

Be careful brushing and flossing your teeth or using a toothpick because you may get an infection or bleed more easily. If you have any dental work done, tell your dentist you are receiving this drug.

This drug quickly kills leukemia cells which may result in a syndrome called 'tumor lysis syndrome'. If you experience symptoms such as fast breathing, fast heartbeat, dizziness, and difficulty breathing, call your doctor immediately.

Avoid taking products that contain aspirin, acetaminophen, ibuprofen, naproxen, or ketoprofen unless instructed by your doctor. These medicines may hide a fever.

Women should inform their doctor if they wish to become pregnant or think they might be pregnant. There is a potential for serious side effects to an unborn child. Talk to your health care professional or pharmacist for more information. Do not breast-feed an infant while taking this medicine.

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Note: This information is not intended to cover all possible uses, precautions, interactions, or adverse effects for this drug. If you have question about the drug(s) you are taking, check with your health care professional.
 
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