DIPHENHYDRAMINE; PHENYLEPHRINE (dye fen HYE dra meen; fen il EF rin) is a combination of an antihistamine and a decongestant. It is used to treat the symptoms of allergies, a cold, or other sinus problems. It may help with congestion and runny nose. This medicine will not treat an infection.
What should I tell my health care provider before I take this medicine?
They need to know if you have any of these conditions:
high blood pressure
stomach ulcer or obstruction
taken an MAOI like Carbex, Eldepryl, Marplan, Nardil, or Parnate within the last 14 days
trouble passing urine
an unusual or allergic reaction to diphenhydramine, phenylephrine, other medicines, foods, dyes, or preservatives
pregnant or trying to get pregnant
How should I use this medicine?
Take this medicine by mouth with a glass of water. Follow the directions on the prescription label. Take your medicine at regular intervals. Do not take it more often than directed.
Talk to your pediatrician regarding the use of this medicine in children. While this drug may be prescribed for children as young as 12 years old for selected conditions, precautions do apply.
Patients over 65 years old may have a stronger reaction and need a smaller dose.
What if I miss a dose?
If you miss a dose, take it as soon as you can. If it is almost time for your next dose, take only that dose. Do not take double or extra doses.
What may interact with this medicine?
Do not take this medicine with any of the following medications:
ergot alkaloids like dihydroergotamine, ergonovine, ergotamine, methylergonovine
MAOIs like Carbex, Eldepryl, Marplan, Nardil, and Parnate
stimulant medicines for attention disorders, weight loss, or to stay awake
This medicine may also interact with the following medications:
barbiturates like phenobarbital
medicines for depression, anxiety, or psychotic disturbances
medicines for sleep
narcotic medicines for pain
other medicines for cold, cough, or allergy
St. John's Wort
What should I watch for while using this medicine?
Talk to your doctor or healthcare professional if your symptoms do not start to get better or if they get worse.
This medicine can make you more sensitive to the sun. Keep out of the sun. If you cannot avoid being in the sun, wear protective clothing and use sunscreen. Do not use sun lamps or tanning beds/booths.
You may get drowsy or dizzy. Do not drive, use machinery, or do anything that needs mental alertness until you know how this medicine affects you. Do not stand or sit up quickly, especially if you are an older patient. This reduces the risk of dizzy or fainting spells. Alcohol may interfere with the effect of this medicine. Avoid alcoholic drinks.
What side effects may I notice from receiving this medicine?
Side effects that you should report to your doctor or health care professional as soon as possible:
allergic reactions like skin rash, itching or hives, swelling of the face, lips, or tongue
anxiety, nervous, or restless
changes in blood pressure
changes in vision
fast, irregular heartbeat
problems with balance, talking, or walking
trouble passing urine or change in the amount of urine
unusual bleeding or bruising
unusually weak or tired
Side effects that usually do not require medical attention (report to your doctor or health care professional if they continue or are bothersome):
Note: This information is not intended to cover all possible uses, precautions, interactions, or adverse effects for this drug. If you have question about the drug(s) you are taking, check with your health care professional.