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Generic Name: dornase alfa

It is used to improve how well the lungs work
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What is this medicine?

DORNASE ALFA (DOOR nace AL fa) breaks up lung congestion in patients with cystic fibrosis. It is used to improve how well the lungs work. This medicine also decreases the risk of getting a lung infection.

What should I tell my health care provider before I take this medicine?

They need to know if you have any of these conditions:
  • an unusual or allergic reaction to dornase alfa, animal proteins, other medicines, foods, dyes, or preservatives
  • pregnant or trying to get pregnant
  • breast-feeding

How should I use this medicine?

This medicine is for inhalation using a nebulizer. Nebulizers make a liquid into an aerosol that you breathe in through your mouth or your mouth and nose into your lungs. You will be taught how to use your nebulizer. Follow the directions on your prescription label. Do not dilute or mix with other drugs in the nebulizer. Do not use more often than directed.

Talk to your pediatrician regarding the use of this medicine in children. Special care may be needed. While this drug may be prescribed for children as young as 5 years old for selected conditions, precautions do apply.

What if I miss a dose?

If you miss a dose, use it as soon as you can. If it is almost time for your next dose, use only that dose. Do not use double or extra doses.

What may interact with this medicine?

Interactions are not expected. Do not mix with any other medicines in the nebulizer.

What should I watch for while using this medicine?

Visit your doctor or healthcare professional as directed. Tell your doctor or healthcare professional if your symptoms do not start to get better or if they get worse.

What side effects may I notice from receiving this medicine?

Side effects that you should report to your doctor or health care professional as soon as possible:
  • allergic reactions like skin rash, itching or hives, swelling of the face, lips, or tongue
  • breathing problems
  • change in blood sugar, ask your health care provider for symptoms
  • chest pain
  • dizziness
  • eye irritation or infection
  • fever, flu-like symptoms
  • unusual bleeding or bruising
  • unusually weak or tired

Side effects that usually do not require medical attention (report to your doctor or health care professional if they continue or are bothersome):

  • change in voice
  • cough
  • runny nose
  • sore throat
  • stomach upset, nausea
  • weight loss

Where should I keep my medicine?

Keep out of the reach of children.

Store in a refrigerator between 2 and 8 degrees C (36 and 46 degrees F). Protect from light. Store in foil pouch until ready to use. Do not store at room temperature for more than 24 hours. Do not use if solution is discolored or cloudy. Once opened, the entire ampule must be used or thrown away. Throw away any unopened medicine after the expiration date stamped on the ampule.

Remember, keep this and all other medicines out of the reach of children, never share your medicines with others, and use this medication only for the indication prescribed.


All visitors to AARP.org should seek expert medical care and consult their own physicians for any specific health issues. Read this disclaimer in its entirety.
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Note: This information is not intended to cover all possible uses, precautions, interactions, or adverse effects for this drug. If you have question about the drug(s) you are taking, check with your health care professional.
 
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