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Generic Name: estradiol/medroxyprogesterone

It is a birth-control method to prevent an unwanted pregnancy
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What is this medicine?

ESTRADIOL CYPIONATE; MEDROXYPROGESTERONE (es tra DYE ole sip EYE oh nate; me DROX ee proe JES te rone) is a birth-control method to prevent an unwanted pregnancy. Each injection provides birth control for 1 month (30 days).
NOTE: This drug is discontinued in the United States.

What should I tell my health care provider before I take this medicine?

They need to know if you have or ever had any of these conditions:
  • abnormal vaginal bleeding
  • blood vessel disease or blood clots
  • breast, cervical, endometrial, ovarian, liver, or uterine cancer
  • diabetes
  • gallbladder disease
  • heart disease or recent heart attack
  • high blood pressure
  • high cholesterol
  • kidney disease
  • liver disease
  • migraine headaches
  • stroke
  • systemic lupus erythematosus (SLE)
  • tobacco smoker
  • an unusual or allergic reaction to estrogens, progestins, or other medicines, foods, dyes, or preservatives
  • pregnant or trying to get pregnant
  • breast-feeding

How should I use this medicine?

This medicine is for injection into a muscle. It is given by a health-care professional. The first injection is usually given during the first 5 days after the start of a menstrual period. This medicine will provide birth control for roughly 28 to 30 days.

Talk to your pediatrician regarding the use of this medicine in children. Special care may be needed. This medicine has been used in female children who have started having menstrual periods.

A patient package insert for the product will be given with each prescription and refill. Read this sheet carefully each time. The sheet may change frequently.

What if I miss a dose?

Try not to miss a dose. You will need an injection once per month in order to maintain birth control. If you cannot keep an appointment call to reschedule. If it has been more than 4 weeks (33 days) since your last injection, you will need to have a pregnancy test before you can have another injection.

What may interact with this medicine?

  • acetaminophen
  • antibiotics or medicines for infections, especially rifampin, rifabutin, rifapentine, and griseofulvin, and possibly penicillins or tetracyclines
  • aprepitant
  • ascorbic acid (vitamin C)
  • atorvastatin
  • barbiturate medicines, such as phenobarbital
  • bosentan
  • carbamazepine
  • caffeine
  • clofibrate
  • cyclosporine
  • dantrolene
  • doxercalciferol
  • felbamate
  • grapefruit juice
  • hydrocortisone
  • medicines for anxiety or sleeping problems, such as diazepam or temazepam
  • medicines for diabetes, including pioglitazone
  • mineral oil
  • modafinil
  • mycophenolate
  • nefazodone
  • oxcarbazepine
  • phenytoin
  • prednisolone
  • ritonavir or other medicines for HIV infection or AIDS
  • rosuvastatin
  • selegiline
  • soy isoflavones supplements
  • St. John's wort
  • tamoxifen or raloxifene
  • theophylline
  • thyroid hormones
  • topiramate
  • warfarin

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All visitors to AARP.org should seek expert medical care and consult their own physicians for any specific health issues. Read this disclaimer in its entirety.
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Note: This information is not intended to cover all possible uses, precautions, interactions, or adverse effects for this drug. If you have question about the drug(s) you are taking, check with your health care professional.
 
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