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Generic Name: Kombiglyze Xr

What is this medicine?

METFORMIN; SAXAGLIPTIN (met FOR min; SAX a glip tin) is a combination of 2 medicines used to treat type 2 diabetes. This medicine lowers blood sugar. Treatment is combined with a balanced diet and exercise.

What should I tell my health care provider before I take this medicine?

They need to know if you have any of these conditions:

become easily dehydrated
diabetic ketoacidosis
gallstones
heart disease
high levels of triglyceride in the blood
history of alcohol abuse problem
history of pancreatitis
if you often drink alcohol
kidney disease
liver disease
low levels of vitamin B12 in the blood
older than 80 years
polycystic ovary syndrome
serious infection or injury
thyroid disease
type 1 diabetes
an unusual or allergic reaction to metformin, saxagliptin, other medicines, foods, dyes, or preservatives
pregnant or trying to get pregnant
breast-feeding

How should I use this medicine?

Take this medicine by mouth with a glass of water. Follow the directions on the prescription label. Take this medicine with the evening meal. Do not cut, crush or chew this medicine. Take your medicine at regular intervals. Do not take your medicine more often than directed. Do not stop taking except on your doctor's advice.

A special MedGuide will be given to you by the pharmacist with each prescription and refill. Be sure to read this information carefully each time.

Talk to your pediatrician regarding the use of this medicine in children. Special care may be needed.

Overdosage: If you think you've taken too much of this medicine contact a poison control center or emergency room at once.

What if I miss a dose?

If you miss a dose, take it as soon as you can. If it is almost time for your next dose, take only that dose. Do not take double or extra doses.

What may interact with this medicine?

Do not take this medicine with any of the following medications:

certain contrast medicines given before X-rays, CT scans, MRI, or other procedures
dofetilide
gatifloxacin

This medicine may also interact with the following medications:

amiloride
antiviral medicines for HIV or AIDS
calcium channel blockers
certain antibiotics like clarithromycin and telithromycin
certain medicines for fungal infections like ketoconazole and itraconazole
cimetidine
digoxin
diuretics
female hormones, like estrogens or progestins and birth control pills
isoniazid
medicines for diabetes
morphine
nefazodone
niacin, niacinamide
phenothiazines like chlorpromazine, mesoridazine, prochlorperazine, thioridazine
phenytoin
procainamide
quinidine
quinine
ranitidine
steroid medicines like prednisone or cortisone
stimulant medicines for attention disorders, weight loss, or to stay awake
thyroid medicines
trimethoprim
vancomycin

What should I watch for while using this medicine?

Visit your doctor or health care professional for regular checks on your progress.

Learn how to check your blood sugar. Learn the symptoms of high or low blood sugar and how to manage them.

If you have low blood sugar, eat or drink something that has sugar. Make sure others know to get medical help quickly if you have serious symptoms of low blood sugar, like if you become unconscious or have a seizure.

If you need surgery or if you will need a procedure with contrast drugs, tell your doctor or health care professional that you are taking this medicine.

Wear a medical identification bracelet or chain to say you have diabetes, and carry a card that lists all your medications.

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All visitors to AARP.org should seek expert medical care and consult their own physicians for any specific health issues. Read this disclaimer in its entirety.

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Note: This information is not intended to cover all possible uses, precautions, interactions, or adverse effects for this drug. If you have question about the drug(s) you are taking, check with your health care professional.

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