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Generic Name: dehydroepiandrosterone

What is this medicine?

PRASTERONE is a prescription medicine also known as DHEA. DHEA is similar to a hormone produced in the body. It is used for treating systemic lupus erythematosis (SLE or 'lupus'). It is not a cure.

What should I tell my health care provider before I take this medicine?

They need to know if you have any of these conditions:
  • breast cancer (men or women)
  • cancer of the lining of the uterus (endometrial cancer)
  • diabetes or high blood sugar
  • immune system problems
  • infertility
  • liver disease
  • post-menopause
  • prostate cancer or an enlarged prostate gland
  • rheumatoid arthritis
  • uterine cancer
  • vaginal bleeding or menstrual problems
  • vaginal cancer
  • an unusual or allergic reaction to Prasterone, DHEA, soy, other medicines, foods, dyes, or preservatives
  • pregnant or trying to get pregnant
  • breast-feeding

How should I use this medicine?

Take this medicine by mouth with a glass of water. Follow the directions on the prescription label. Take your medicine at regular intervals. Do not take your medicine more often than directed. Do not stop taking except on your doctor's advice.

Talk to your pediatrician regarding the use of this medicine in children. This medicine is not approved for use in children.

What if I miss a dose?

If you miss a dose, take it as soon as you can. If it is almost time for your next dose, take only that dose. Do not take double or extra doses.

What may interact with this medicine?

Do not take this medicine with any of the following medications:
  • dietary supplements containing DHEA

This medicine may also interact with the following medications:

  • alprazolam
  • aspirin
  • cilostazol
  • clopidogrel
  • male hormones (such as methyltestosterone or testosterone)
  • female hormones, like estrogens or progestins and birth control pills, patches, rings, or injections
  • fertility treatments (such as clomiphene, or fertility injections)
  • leuprolide
  • medicines for diabetes
  • medicines for sleep
  • saw palmetto
  • steroid medicines like prednisone or cortisone
  • ticlopidine
  • warfarin

What should I watch for while using this medicine?

Visit your doctor or health care professional for regular checks on your progress. Tell your doctor or healthcare professional if your symptoms do not start to get better or if they get worse.

Women should inform their doctor if they wish to become pregnant or think they might be pregnant. There is a potential for serious side effects to an unborn child. Talk to your health care professional or pharmacist for more information.

DHEA use is banned in competitive sports. Both college (NCAA) and olympic (USOC) committees do not allow DHEA use among athletes.

What side effects may I notice from receiving this medicine?

Side effects that you should report to your doctor or health care professional as soon as possible:

  • breast pain, swelling, or change in breast appearance
  • trouble passing urine or change in the amount of urine
  • dark urine
  • general ill feeling or flu-like symptoms
  • hair growth in unusual places
  • hoarseness of the voice
  • light-colored stools
  • nausea, vomiting
  • menstrual changes
  • right upper belly pain
  • unusually weak or tired
  • yellowing of the eyes or skin

Side effects that usually do not require medical attention (report to your doctor or health care professional if they continue or are bothersome):

  • change in sex drive or performance
  • headache
  • loss of appetite

Where should I keep my medicine?

Keep out of the reach of children.

Store at room temperature between 15 and 30 degrees C (59 and 86 degrees F). Throw away any unused medicine after the expiration date.

Remember, keep this and all other medicines out of the reach of children, never share your medicines with others, and use this medication only for the indication prescribed.

All visitors to AARP.org should seek expert medical care and consult their own physicians for any specific health issues. Read this disclaimer in its entirety.
Note: This information is not intended to cover all possible uses, precautions, interactions, or adverse effects for this drug. If you have question about the drug(s) you are taking, check with your health care professional.
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