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What is this medicine?

SAPROPTERIN (SAP roe TER in) works to lower phenylalanine levels in the blood. It is used with a special diet to treat phenylketonuria. This medicine is not a cure.

What should I tell my health care provider before I take this medicine?

They need to know if you have any of these conditions:
  • eating disorder like anorexia, bulimia
  • fever
  • infection
  • kidney disease
  • liver disease
  • seizures
  • an unusual or allergic reaction to sapropterin, other medicines, foods, dyes, or preservatives
  • pregnant or trying to get pregnant
  • breast-feeding

How should I use this medicine?

Take this medicine by mouth with food. Follow the directions on the prescription label. Dissolve tablets in 4 to 8 ounces (1/2 to 1 cup) of water or apple juice. Drink within 15 minutes of mixing. To make tablets dissolve faster, you may crush or stir them. Tablets may not dissolve completely, and you may see small pieces floating in the glass. If small pieces remain in the glass after taking the medicine, add more water or apple juice to the glass and drink it to make sure you get all of the medicine. Take your medicine at regular intervals. Do not take it more often than directed. Do not stop taking except on your doctor's advice.

Talk to your pediatrician regarding the use of this medicine in children. While this drug may be prescribed for children as young as 4 years of age for selected conditions, precautions do apply.

What if I miss a dose?

If you miss a dose, take it as soon as you can. If it is almost time for your next dose, take only that dose. Do not take double or extra doses.

What may interact with this medicine?

  • levodopa
  • medicines for erectile dysfunction
  • methotrexate

What should I watch for while using this medicine?

Your condition will be monitored carefully while you are receiving this medicine. Visit your doctor for regular check ups and for blood tests. It may take up to 4 weeks for your body to respond to this medicine.

Tell your doctor or health care professional if your symptoms do not start to get better or if they get worse.

You will need to be on a special diet while you are taking this medicine. Talk with your health care professional before making any changes to your diet.

What side effects may I notice from receiving this medicine?

Side effects that you should report to your doctor or health care professional as soon as possible:
  • allergic reactions like skin rash, itching or hives, swelling of the face, lips, or tongue
  • fever, chills or sore throat
  • seizures

Side effects that usually do not require medical attention (report to your prescriber or health care professional if they continue or are bothersome):

  • abdominal pain
  • diarrhea
  • dizziness
  • headache
  • nausea, vomiting
  • runny or congested nose

Where should I keep my medicine?

Keep out of the reach of children.

Store at room temperature between 20 and 25 degrees C (68 and 77 degrees F). Store this medicine in the original container. Keep the container tightly closed. Throw away any unused medicine after the expiration date.

Remember, keep this and all other medicines out of the reach of children, never share your medicines with others, and use this medication only for the indication prescribed.


All visitors to AARP.org should seek expert medical care and consult their own physicians for any specific health issues. Read this disclaimer in its entirety.
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Note: This information is not intended to cover all possible uses, precautions, interactions, or adverse effects for this drug. If you have question about the drug(s) you are taking, check with your health care professional.
 
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