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Generic Name: trimethobenzamide

This medicine is also used to control nausea caused by stomach problems
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What is this medicine?

TRIMETHOBENZAMIDE (trye meth oh BEN za mide) helps to control nausea and vomiting after surgery. This medicine is also used to control nausea caused by stomach problems.

NOTE: This drug is no longer available in the United States. Patients currently using Trimethobenzamide suppositories should contact their prescriber about stopping this medicine and finding alternative therapies.

What should I tell my health care provider before I take this medicine?

They need to know if you have any of these conditions:
  • an unusual or allergic reaction to trimethobenzamide, benzocaine, other medicines, foods, dyes, or preservatives
  • pregnant or trying to get pregnant
  • breast-feeding

How should I use this medicine?

This medicine is for rectal use only. Do not take by mouth. Wash your hands before and after use. Take off the foil wrapping. Wet the tip of the suppository with cold tap water to make it easier to use. Lie on your side with your lower leg straightened out and your upper leg bent forward toward your stomach. Lift upper buttock to expose the rectal area. Apply gentle pressure to insert the suppository completely into the rectum, pointed end first. Hold buttocks together for a few seconds. Remain lying down for about 15 minutes to avoid having the suppository come out. Do not use more often than directed.

Talk to your pediatrician regarding the use of this medicine in children. While this medicine may be prescribed for certain conditions, precautions do apply. This medicine should not be used in infants or premature infants.

What if I miss a dose?

If you miss a dose, use it as soon as you can. If it is almost time for your next dose, use only that dose. Do not use double or extra doses.

What may interact with this medicine?

Do not take this medicine with any of the following medications:
  • phenothiazines like chlorpromazine, mesoridazine, prochlorperazine, thioridazine

This medicine may also interact with the following medications:

  • alcohol
  • atropine, belladonna alkaloids, hyoscyamine, scopolamine
  • medicines for pain
  • medicines for sleep or anxiety
  • phenobarbital or other barbiturates

What should I watch for while using this medicine?

If your condition gets worse after taking this medicine, contact your health care professional immediately.

You may get drowsy or dizzy or have blurred vision. Do not drive, use machinery, or do anything that needs mental alertness until you know how this medicine affects you. Do not stand or sit up quickly, especially if you are an older patient. This reduces the risk of dizzy or fainting spells. Alcohol may increase side effects of this medicine. Avoid alcoholic drinks.

What side effects may I notice from receiving this medicine?

Side effects that you should report to your doctor or health care professional as soon as possible:
  • allergic reactions like skin rash, itching or hives, swelling of the face, lips, or tongue
  • breathing problems
  • shakiness or tremors
  • seizures
  • severe or continuing vomiting
  • sore throat or fever
  • swelling of the hands and feet
  • tightness in the chest
  • yellowing of the eyes or skin
  • unusually tired

Side effects that usually do not require medical attention (report to your doctor or health care professional if they continue or are bothersome):

  • diarrhea
  • headache
  • muscle cramps

Where should I keep my medicine?

Keep out of the reach of children.

Store at room temperature between 15 and 30 degrees C (59 and 86 degrees F). Throw away any unused portion after the expiration date.

Remember, keep this and all other medicines out of the reach of children, never share your medicines with others, and use this medication only for the indication prescribed.


All visitors to AARP.org should seek expert medical care and consult their own physicians for any specific health issues. Read this disclaimer in its entirety.
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Note: This information is not intended to cover all possible uses, precautions, interactions, or adverse effects for this drug. If you have question about the drug(s) you are taking, check with your health care professional.
 
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