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Chronic Lymphocytic Leukemia

What Is Chronic Lymphocytic Leukemia?

Leukemia is a type of cancer involving your blood cells and blood-forming tissues. There are many types of leukemia, each affecting different kinds of blood cells. Chronic lymphocytic leukemia, or CLL, affects your lymphocytes.

Lymphocytes are a type of white blood cell. CLL affects B lymphocytes, which are also called B cells. Normal B cells circulate in your blood and help your body fight infection. Cancerous B cells don’t fight infections like normal B cells do. As the number of cancerous B cells gradually increases, they crowd out normal lymphocytes and cause bone marrow failure.

Experts don’t know what causes CLL.

What Are the Symptoms of CLL?

Some people with CLL may not have any symptoms, and their cancer may only be discovered during a routine blood test. If you do exhibit symptoms, they typically include:

  • fatigue
  • fever
  • frequent infections or illness
  • unexplained or unintended weight loss
  • night sweats

During a physical examination, your doctor may also find that your spleen, liver, or lymph nodes are enlarged. These can be signs that your cancer has spread to these organs. This often happens in advanced cases of CLL. If this happens to you, you may feel painful lumps in your neck or a sensation of fullness or swelling in your belly.

What Are the Risk Factors for CLL?

CLL is rarely diagnosed in people under the age of 40 years old. It’s typically found in people over the age of 70. It affects more men than women. It’s more common in Jewish people of Russian or Eastern European descent.

How Is CLL Diagnosed and Staged?


If your doctor suspects you have CLL, they may use various tests to confirm your diagnosis. For example, they will probably order one or more of the following tests.

Complete Blood Count (CBC) with White Blood Cell Differential

Your doctor can use this blood test to measure the number of different types of cells in your blood, including different types of white blood cells. If you have CLL, you will have more lymphocytes than normal.

Immunoglobulin Testing

Your doctor can use this blood test to learn if you have enough antibodies to fight infections.

Bone Marrow Biopsy

In this procedure, your doctor will insert a needle with a special tube into your hip or breastbone to get a sample of your bone marrow for testing.

CT Scan

Your doctor can use the pictures created by this scan to look for swollen lymph nodes in your chest or abdomen.


If you’re diagnosed with CLL, your doctor will order further testing to gauge the extent of the disease. This helps your doctor classify the stage of your cancer, which will guide your treatment plan. To stage your CLL, your doctor will probably order blood tests to obtain your red blood cell count and specific blood lymphocyte count. They will also probably check if your lymph nodes, spleen, or liver are enlarged.

Under the "Rai" system of classification, CLL is staged from 0 to 4. Rai stage 0 CLL is the least severe, while Rai stage 4 is the most severe. For treatment purposes, the stages are also grouped into levels of risk. Rai stage 0 is low risk, Rai stages 1 and 2 are intermediate risk, and Rai stages 3 and 4 are high risk, explains the American Cancer Society.

What Is the Treatment for CLL?

If you have low-risk CLL, your doctor will probably advise you to simply wait and watch for new symptoms. Your disease may not worsen or require treatment for years. Some people never require treatment.

In some cases of low-risk CLL, your doctor may recommend treatment. For example, they may recommend it if you have:

  • persistent, recurrent infections
  • low blood cell counts
  • fatigue or night sweats
  • painful lymph nodes

If you have intermediate- or high-risk CLL, your doctor will probably advise you to proceed with treatment right away.

To treat CLL, your doctor may recommend:


This procedure, which is the principal treatment for CLL, involves using medications to kill cancer cells. Depending on the exact medications prescribed, you may take them intravenously or orally.


In this procedure, high-energy particles or waves are used to kill cancer cells. If you have painful swollen lymph nodes, radiation therapy may help shrink them and relieve your pain. 

Blood Transfusions

If your blood cell counts are low, you may need to receive blood transfusions through an intravenous (IV) line to increase them.

Bone Marrow or Peripheral Blood Stem Cell Transplant

If you have high-risk CLL, this treatment may be an option. It involves taking stem cells from the bone marrow or blood of a donor — usually a family member — and transplanting them into your body to help establish a new immune system.

Are There Any Possible Complications of Treatment?

Chemotherapy weakens your immune system, leaving you more vulnerable to infections. You may also develop abnormal levels of antibodies and low blood cell counts during chemotherapy.

Other common side effects of chemotherapy include:

  • fatigue
  • hair loss
  • mouth sores
  • loss of appetite
  • nausea and vomiting

In some cases, chemotherapy can contribute to the development of other cancers.

Radiation, blood transfusions, and bone marrow or peripheral blood stem cell transplants can also involve side effects. Talk with your doctor about the expected side effects of your treatment. They can tell you which symptoms and side effects require medical attention.

What Is the Long-Term Outlook for CLL?

Survival rates for CLL vary widely. Your age, gender, chromosome abnormalities, and cancer cell characteristics can affect your outlook. The disease is rarely cured, but most people live for many years with CLL, reports the American Cancer Society.

Ask your doctor about your specific case. They can help you understand how far your cancer has progressed. They can also discuss your treatment options and long-term outlook.

Content licensed from:

Written by: Jaime Herndon
Medically reviewed on: Mar 21, 2016: Steve Kim, MD

This feature is for informational purposes only and should not be used to replace the care and information received from your health care provider. Please consult a health care professional with any health concerns you may have.
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