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Diuretics: What to Know


Diuretics, also called water pills, are medications designed to increase the amount of water and salt expelled from the body as urine. There are three types of prescription diuretics. They’re often prescribed to help treat high blood pressure, but they're used for other conditions as well.

What diuretics help treat

The most common condition treated with diuretics is high blood pressure. The drugs reduce the amount of fluid in your blood vessels, and this helps lower your blood pressure.

Other conditions are also treated with diuretics. Congestive heart failure, for instance, keeps your heart from pumping blood effectively throughout your body. This leads to a buildup of fluids in your body, which is called edema. Diuretics can help reduce this fluid buildup.

Types of diuretics

The three types of diuretic medications are called thiazide, loop, and potassium-sparing diuretics. All of them make your body excrete more fluids as urine.

Thiazide diuretics

Thiazides are the most commonly prescribed diuretics. They’re most often used to treat high blood pressure. These drugs not only decrease fluids in your body, they also cause your blood vessels to relax. Thiazides are sometimes taken with other medications used to lower blood pressure. Examples of thiazides include:

Loop diuretics

Loop diuretics are often used to treat heart failure. Examples of these drugs include:

Potassium-sparing diuretics

Potassium-sparing diuretics reduce fluid levels in your body without causing you to lose potassium, an important nutrient. The other types of diuretics cause you to lose potassium, which can lead to health problems such as arrhythmia. Potassium-sparing diuretics may be prescribed for people at risk of low potassium levels, such as those who take other drugs that deplete potassium.

Potassium-sparing diuretics don’t reduce blood pressure as well as the other types of diuretics do. Therefore, your doctor may prescribe a potassium-sparing diuretic with another drug that also lowers blood pressure.

Examples of potassium-sparing diuretics include:

Side effects of diuretics

When taken as prescribed, diuretics are generally well tolerated. However, they can still cause some side effects.

More common side effects

The more common side effects of diuretics include:

Serious side effects

In rare cases, diuretics may cause serious side effects. These can include:

What you can do

If you have side effects that bother you while taking diuretics, talk to your doctor. They may prescribe a different medication or combination of medications to help reduce your side effects.

Whether or not you have side effects, don’t stop taking your diuretic without first talking to your doctor.

Risks of diuretics

Diuretics are generally safe, but there are some risks if you have other medical conditions or take certain medications.

Conditions of concern

Before you take a prescribed diuretic, be sure to tell your doctor if you have any of the following conditions or issues:

Drug interactions

Any time you begin a new medication, you should tell your doctor about any other drugs, supplements, or herbs you’re taking. Be sure to tell your doctor if you take any medications that might interact with a diuretic. These include:

Talk with your doctor

Prescription diuretics can be helpful in treating serious conditions, such as heart failure, to less pressing conditions, such as mild high blood pressure. If your doctor prescribes a diuretic for you, feel free to ask them any questions you may have. Consider discussing these questions:

  • How will I know my diuretic is working the way it’s supposed to work?
  • Am I taking any medications that might interact with a diuretic?
  • Should I follow a low-salt diet while taking a diuretic?
  • Should I have my blood pressure and kidney function tested while taking this drug?
  • Should I take a potassium supplement or avoid foods that contain potassium?

Content licensed from:

Written by: Mary Ellen Ellis
Medically reviewed on: Nov 07, 2016: Philip Gregory, PharmD, MS

This feature is for informational purposes only and should not be used to replace the care and information received from your health care provider. Please consult a health care professional with any health concerns you may have.
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