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Malabsorption Syndrome

What is malabsorption syndrome?

The main role of your small intestine is to absorb nutrients from the food you eat into your bloodstream. Malabsorption syndrome refers to a number of disorders in which the small intestine can’t absorb enough of certain nutrients and fluids. These nutrients can be macronutrients (proteins, carbohydrates, and fats), micronutrients (vitamins and minerals), or both.

Causes of malabsorption syndrome

Many things can lead to malabsorption syndrome, from certain diseases to infections or birth defects.

Possible causes

Factors that may cause malabsorption syndrome include:

The syndrome may also be caused by digestive problems. Your stomach may not be able to produce the enzymes it needs to digest certain foods. Or your body may not be able to mix the food you eat with the enzymes and acid produced by your stomach.

Rare causes

There are also some uncommon disorders that can result in malabsorption. One of these is called short bowel syndrome (SBS). With this condition, the small intestine is shortened. This makes the intestine less able to absorb nutrients. SBS may be a birth defect, or it may be caused by surgery.

Certain diseases may cause malabsorption. These include tropical sprue, a condition most common in the Caribbean, India, and other parts of Southeast Asia. This disease may be related to environmental factors, such as toxins in food, infection, or parasites. An even rarer potential cause of malabsorption is Whipple’s disease, which is a result of a bacterial infection.

Recognizing the symptoms of malabsorption syndrome

Symptoms of malabsorption syndrome are caused when unabsorbed nutrients pass through the digestive tract.

Many symptoms differ depending on the specific nutrient or nutrients that are not being absorbed properly. Other symptoms are a result of a deficiency of that nutrient, which is caused by its poor absorption. For instance, you may have the following symptoms if you’re unable to absorb fats, protein, or certain sugars or vitamins:

Malabsorption may affect people based on age or gender. For instance, women may stop menstruating, and children may not grow properly. Their weight or rate of weight gain may be significantly below that of other children of a similar age and gender. Another sign of malabsorption in children is that they may purposefully avoid certain foods.

Risk factors

Risk factors for malabsorption syndrome include:

  • a family history of cystic fibrosis or malabsorption
  • drinking large amounts of alcohol
  • intestinal surgery
  • use of certain medications, including laxatives or mineral oil
  • travel to the Caribbean, India, and other parts of Southeast Asia

Diagnosing malabsorption syndrome

Your doctor may suspect malabsorption syndrome if you have chronic diarrhea or nutrient deficiencies, or have lost a significant amount of weight despite eating a healthy diet. Certain tests are used to confirm the diagnosis. These tests may include:

Stool tests

Stool tests can measure fat in samples of stool (feces). These tests are the most reliable because fat is usually present in the stool of someone with malabsorption syndrome.

Blood tests

These tests measure the level of specific nutrients in your blood, such as vitamin B-12, vitamin D, folate, iron, calcium, carotene, phosphorus, albumin, and protein. A lack of one of these nutrients may not necessarily mean you have malabsorption syndrome. It can mean you are not choosing foods with healthy levels of nutrients. Normal levels of these nutrients suggest that malabsorption is not the problem.

Breath tests

Breath tests can be used to test for lactose intolerance. If lactose is not being absorbed, it enters the colon. Bacteria in the colon break down the lactose and produce hydrogen gas. The excess hydrogen is absorbed from your intestine, into your bloodstream, and then into your lungs. You will then exhale the gas.

If you have hydrogen gas in your breath after ingesting a product containing lactose, you may have lactose intolerance.

Imaging tests

Imaging tests, which take pictures of your digestive system, may be done to look for structural problems. For instance, a CT scan may be done to look for thickening of the wall of your small intestine, which could be a sign of Crohn’s disease.


You may have a biopsy if your doctor suspects that you have abnormal cells in the lining of your small intestine. This test will likely be done using an endoscopy. A tube is inserted into your mouth and sent through your esophagus and stomach and into your small intestine, where it takes a small sample of cells.

Treatment options for malabsorption syndrome

Your doctor will likely start your treatment by addressing symptoms such as diarrhea. Medications such as loperamide can help.

Your doctor will also want to replace the nutrients and fluids that your body has been unable to absorb. And they may monitor you for signs of dehydration, which can include increased thirst, low urine output, and dry mouth, skin, or tongue.

Next, your doctor will provide care based on the cause of the absorption problem. For instance, if you’re found to have lactose intolerance, your doctor will likely advise you to avoid milk and other dairy products or take a lactase enzyme tablet.

At this point, your doctor may refer you to a dietitian. Your dietitian will create a treatment plan that will help make sure you’re getting the nutrients your body needs. Your dietitian may recommend:

  • Enzyme supplements: These supplements can help your body absorb the nutrients it can’t absorb on its own.
  • Vitamin supplements: Your dietitian may recommend high doses of vitamins or other nutrients to make up for those that are not being absorbed by your intestine.
  • Diet changes: Your dietitian may adjust your diet to increase or decrease certain foods or nutrients. For instance, you may be advised to avoid foods high in fat to decrease diarrhea, and increase foods high in potassium to help balance your electrolytes.

Your doctor and your dietitian can help create a treatment plan that will manage your malabsorption symptoms and allow your body to obtain the nutrients and fluids it needs to function normally.

Possible complications

Content licensed from:

Written by: Michael Kerr and Jacquelyn Cafasso
Medically reviewed on: May 23, 2017: University of Illinois-Chicago, College of Medicine

This feature is for informational purposes only and should not be used to replace the care and information received from your health care provider. Please consult a health care professional with any health concerns you may have.
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