Diseases & Conditions A - Z
powered by Talix

Multiple Sclerosis (MS) Tests & Diagnosis

Although there is no single, specific test that can diagnosis multiple sclerosis with 100 percent accuracy, imaging and laboratory testing is very important to assist in the diagnostic process.

Your health care provider may suggest one or more of the following tests to help make a firm diagnosis:


Magnetic resonance imaging (MRI) is the major diagnostic laboratory tool that can support the diagnosis. Particular characteristics of imaging findings include multiplicity of lesions (changes in the brain), large diameter, and ovoid shape in particular locations in the brain typical of MS.

An MRI scanner exerts powerful magnetic fields and radio waves around a patient who lies in a tube. It produces very accurate images of the patient's internal organs—in this case, the brain and the spinal cord in particular. An MRI cross section of the brain and spinal cord can reveal formerly hidden MS lesions.

Spinal Tap

If the MRI findings are inconclusive, the person might have to undergo a lumbar puncture (spinal tap) to examine the cerebrospinal fluid (spinal fluid contents) to evaluate for immunologic  patterns. Spinal fluid provides important complementary information to rule out other conditions related to infections or other diseases as well as to support the diagnosis of MS.

Blood Tests

Blood tests, like spinal taps, are used to exclude other diagnoses.

Evoked Potential Tests

Evoked potential testing can be prescribed when the results continue to be inconclusive. These are tests consist of stimulation of the nerves in the visual pathway, brainstem tract, and spinal cord. When conduction of impulses occurs, these findings can verify the diagnosis of possible multiple sclerosis. These tests are usually painless and non-invasive and can assist the clinician when the final diagnosis is uncertain.

The diagnosis of MS is now facilitated by state-of-the-art laboratory testing but is still based on the clinical expertise of the MS clinician who considers the age, gender, history, and neurologic findings of each person who presents with problems.

Content licensed from:

Written by: June Halper, MSN, APN-C, FAAN, MSCN
Medically reviewed : Jennifer Monti, MD, MPH

This feature is for informational purposes only and should not be used to replace the care and information received from your health care provider. Please consult a health care professional with any health concerns you may have.
Symptom Search
Enter your symptoms in our Symptom Checker to find out possible causes of your symptoms. Go.
Drug Interaction Checker
Enter any list of prescription drugs and see how they interact with each other and with other substances. Go.
Pill Identifier
Enter its color and shape information, and this tool helps you identify it. Go.
Drugs A-Z
Find information on drug interactions, side effects, and more. Go.