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Porphyrias are a group of rare inherited blood disorders. People with these disorders do not make heme, a component of hemoglobin (protein in red blood cells that carries oxygen) properly. Heme is made of porphyrin (a naturally-occurring organic compound in the body) bound to iron. Heme helps red blood cells (RBCs) carry oxygen and also gives RBCs their color. It is also found in myoglobin, a protein in the heart and skeletal muscles.
The body goes through several steps to make heme. However, in people with porphyria, the body lacks certain enzymes needed to complete this process, causing porphyrin to accumulate in tissues and blood. This may cause a variety of symptoms, ranging from mild to severe. The most common symptoms of porphyria are abdominal pain, light sensitivity (causing rashes or blisters), and problems with the muscles and nervous system. The symptoms of porphyria vary and depend on which enzyme is missing.
Porphyria is a genetic disease. According to The Journal of Family Planning (JFP), most types of porphyria are autosomal dominant, meaning that a person only inherits the abnormal gene from one parent. (JFP, 2012) However, certain factors may trigger symptoms, known as "attacks." Factors include:
There are several different types of porphyria, which are classified into two categories: hepatic and erythropoietic. Hepatic forms of the disorder are caused by problems in the liver and are associated with symptoms such as abdominal pain and problems with the central nervous system. Erythropoietic forms are caused by problems in RBCs.
There are five types of hepatic porphyria:
According to the National Center for Biotechnology Information (NCBI), PCT is the most common type of porphyria. It is associated with extreme sensitivity to sunlight. (NCBI, 2011)
Erythropoietic porphyria is associated with light sensitivity. There are two types—muroporphyria and protoporphyria.
Symptoms depend upon the type of porphyria. Severe abdominal pain is present in all types, as well as urine that is reddish-brown in color. This is caused by the build-up of porphyrins, and typically occurs after an attack.
Symptoms associated with hepatic disease include:
Symptoms associated with erythropoietic disease include:
Many tests can help diagnose this condition.
Tests that look for physical problems include:
Tests for blood problems include:
There is no cure for porphyria. Treatment focuses on managing symptoms. Most cases are treated with medication.
Treatments for hepatic disease include:
Treatments for erythropoietic disease include:
Porphyria cannot be prevented. However, symptoms can be reduced by avoiding or eliminating triggers.
Factors that should be eliminated include:
Preventing erythropoietic symptoms focuses on reducing light exposure by:
Porphyria is incurable and difficult to manage. Complications are common. They include:
Long-term outlook varies widely. Patients may not be diagnosed until after damage has been done.
Permanent damage may include:
Early diagnosis can help you lead a relatively normal life. Management is also very important.
If you have an inherited condition, talk to a genetic counselor. He or she can help you understand the risk of passing it to your children.
Written by: Lydia Krause
Medically reviewed : George Krucik, MD
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