Diseases & Conditions A - Z
powered by Talix

Reye's Syndrome

What is Reye’s syndrome?

Reye's syndrome is a rare disorder that causes brain and liver damage. Although it can happen at any age, it is most often seen in children.

Reye’s syndrome usually occurs in children who have had a recent viral infection, such as chickenpox or the flu. Taking aspirin to treat such an infection greatly increases the risk of Reye’s.

Both chickenpox and the flu can cause headaches. That’s why it’s important to not use aspirin to treat a child's headache. Your child may have an undetected viral infection and be at risk of developing Reye’s syndrome.

What are the symptoms of Reye’s syndrome?

Symptoms of Reye's syndrome come on quickly. They generally appear over the course of several hours.

The first symptom of Reye’s is usually vomiting. This is followed by irritability or aggressiveness. After that, children may become confused and lethargic. They may have seizures or fall into a coma.

There is no cure for Reye’s syndrome. However, symptoms can sometimes be managed. For example, steroids help reduce swelling in the brain.


Experts aren’t sure what exactly causes Reye’s syndrome. Several factors may play a role. There’s strong evidence showing that it can be triggered when people treat a viral infection with aspirin. It seems to occur in children and teenagers who have an underlying fatty acid oxidation disorder. This is a type of metabolic disorder that causes the body to be unable to break down fatty acids. Other over-the-counter medications may also contain salicylates similar to those found in aspirin. For example, they are also found in:

  • bismuth subsalicylate (Pepto-Bismol, Kaopectate)
  • products containing oil of wintergreen (these are generally topical medications)

These products should not be given to children who may have, or have had, a viral infection. They should also be avoided for several weeks after your child has received the chickenpox vaccine.

In addition, it’s thought that exposure to certain chemicals like paint thinners or herbicides can contribute to the development of Reye’s syndrome.

Prevalence and risk factors

Children and teenagers with underlying fatty acid oxidation disorders are those at highest risk for Reye’s syndrome. Screening tests can reveal if your child has this disorder. According to the Mayo Clinic, in some cases Reye’s may be an underlying metabolic condition that is exposed by a virus.

If you use aspirin to treat symptoms of your child or teenager’s viral infection, they are at high risk for developing Reye’s syndrome.

Reye’s syndrome is extremely rare, which is partially why our knowledge about it is still limited. Fewer than 20 cases have been reported annually since 1988. The survival rate for Reye’s syndrome is about 80 percent.


Reye's is a serious condition and can be a medical emergency, so early treatment is essential. It’s typically treated with hospitalization. In severe cases, children will be treated in the intensive care unit.

There’s no cure for Reye’s syndrome, so treatment is supportive, focusing on reducing symptoms and complications. Doctors will make sure the child stays hydrated and maintains balanced electrolytes. They’ll evaluate cardiorespiratory (heart and lung) status, and liver function will be carefully monitored. Children with seizures will be given appropriate medications to control them and their side effects.

Medications often used to treat Reye’s syndrome include:

  • insulin to increase glucose metabolism
  • corticosteroids to reduce brain swelling
  • diuretics to get rid of excess fluid

In severe cases, a breathing machine or respirator may be used if the child’s breathing is ineffective or too slow.

The earlier Reye’s syndrome is diagnosed, the better the outcome for the child. If a person progresses to late stages of the syndrome, they may end up with permanent brain damage.

Picture of Reye’s syndrome

Preventing Reye’s syndrome

Reye’s syndrome has become less common. This is because doctors and parents no longer routinely give aspirin to children.

If your child has a headache, it’s usually best to stick to acetaminophen (Tylenol) for treatment. However, make certain to use only the recommended amount. Too much Tylenol can damage the liver.

If a child’s pain or fever is not diminished by Tylenol, see a doctor.

What is the long-term outcome of Reye’s syndrome?

Reye’s syndrome is rarely fatal. However, it can cause varying degrees of permanent brain damage. Take your child to the emergency room immediately if you see signs of:

  • confusion
  • lethargy
  • other mental symptoms

Content licensed from:

Written by: Cindie Slightham and Ana Gotter
Medically reviewed on: Nov 18, 2016: Karen Gill, MD

This feature is for informational purposes only and should not be used to replace the care and information received from your health care provider. Please consult a health care professional with any health concerns you may have.
Symptom Search
Enter your symptoms in our Symptom Checker to find out possible causes of your symptoms. Go.
Drug Interaction Checker
Enter any list of prescription drugs and see how they interact with each other and with other substances. Go.
Pill Identifier
Enter its color and shape information, and this tool helps you identify it. Go.
Drugs A-Z
Find information on drug interactions, side effects, and more. Go.