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Trismus-Pseudocamptodactyly Syndrome (TPS)

What is trismus-pseudocamptodactyly syndrome?

Trismus-pseudocamptodactyly syndrome (TPS) is a rare muscle disorder that affects the mouth, hands, and feet. The syndrome is also known as Dutch-Kennedy syndrome and Hecht syndrome. Learn more about this syndrome.

What are the symptoms of TPS?

The symptoms of TPS vary from one person to another. It causes shortened muscles and tendons. The most common symptom is limited mobility of the mouth, which can cause problems with chewing. Other symptoms can include:

  • limited motion of the arms or legs
  • clenched fists
  • a club foot
  • abnormalities of the feet and hands

What causes TPS?

TPS is an inherited disease. A mutation of the MYH8 gene causes TPS. It’s autosomal dominant. This means that a person can inherit the abnormal gene from only one parent. The only known risk factor for this condition is a family history of TPS.

How is TPS diagnosed?

A doctor can usually diagnose TPS at birth. It requires a full physical examination. A doctor will also look at the family’s medical history because TPS is an inherited syndrome. The signs of TPS begin to show during infancy.

How is TPS treated?

No cure for TPS is available. However, you can have surgery to alleviate some of the symptoms of TPS. Doctors also often suggest physical and occupational therapy for people with TPS who have trouble walking or who have dexterity issues.

Content licensed from:

Written by: Joe Bowman
Medically reviewed on: Jun 08, 2016: Debra Sullivan, PhD, MSN, CNE, COI

This feature is for informational purposes only and should not be used to replace the care and information received from your health care provider. Please consult a health care professional with any health concerns you may have.
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